Journal of cancer research and therapeutics, 2018-04, Vol.14 (3), p.651-657
2018
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- Autor(en) / Beteiligte
- Titel
- Modulation of risk of squamous cell carcinoma head and neck in North Indian population with polymorphisms in xeroderma pigmentosum complementation Group C gene
- Ist Teil von
- Journal of cancer research and therapeutics, 2018-04, Vol.14 (3), p.651-657
- Ort / Verlag
- India: Wolters Kluwer India Pvt. Ltd
- Erscheinungsjahr
- 2018
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Background: Genetic variations in nucleotide excision repair genes can alter the risk of squamous cell carcinoma of head and neck (SCCHN). Materials and Methods: The present study has genotyped 334 subjects from North Indian population for xeroderma pigmentosum complementation Group C (XPC) rs2228001A>C, XPC rs77907221 polyadenylate (PAT) deletion/insertion (D/I), xeroderma pigmentosum complementation Group D - rs13181A>C, and xeroderma pigmentosum complementation Type G rs17655 G>C polymorphisms with polymerase chain reaction (PCR)-restriction-fragment length polymorphism or allele-specific PCR methods. Results: Compared to D allele, I allele for XPC PAT D/I polymorphism was associated with significantly decreased the risk of SCCHN (odds ratios = 0.67, 95% confidence interval [CI] =0.48-0.94, P = 0.03). Haplotype CI constituted from XPC polymorphisms was also associated with decreased risk of SCCHN (P = 0.004). In contrast, haplotype Crohn's disease significantly increased the risk for SCCHN (P < 0.00). A significant early onset of SCCHN was observed in individuals with CC genotype for XPC A>C polymorphism (P = 0.004). Conclusion: Our results suggest a possible risk modulation for SCCHN with XPC polymorphisms in North Indian population.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0973-1482eISSN: 1998-4138DOI: 10.4103/jcrt.JCRT_358_17Titel-ID: cdi_proquest_miscellaneous_2054922236
- Format
- –
- Schlagworte
- Adolescent, Adult, Aged, Aged, 80 and over, Asians - genetics, Biomarkers, Tumor - genetics, Bladder cancer, Carcinoma, Squamous Cell - epidemiology, Carcinoma, Squamous Cell - genetics, Carcinoma, Squamous Cell - pathology, Case-Control Studies, Deoxyribonucleic acid, DNA, DNA damage, DNA repair, DNA-Binding Proteins - genetics, Esophagus, Female, Follow-Up Studies, Genes, Genetic aspects, Genetic polymorphisms, Genetic Predisposition to Disease, Genomics, Head and neck cancer, Head and Neck Neoplasms - epidemiology, Head and Neck Neoplasms - genetics, Head and Neck Neoplasms - pathology, Humans, India - epidemiology, Male, Middle Aged, Polymorphism, Single Nucleotide, Population, Prognosis, Radiation therapy, Risk factors, Skin cancer, Smoking, Squamous cell carcinoma, Studies, Systematic review, Xeroderma pigmentosum, Young Adult