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Mechanochemical Rhodium(III)‐ and Gold(I)‐Catalyzed C−H Bond Alkynylations of Indoles under Solventless Conditions in Mixer Mills
Ist Teil von
Angewandte Chemie (International ed.), 2018-08, Vol.57 (33), p.10723-10727
Auflage
International ed. in English
Ort / Verlag
Germany: Wiley Subscription Services, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Mechanochemical activations in RhIII‐ and AuI‐catalyzed C−H alkynylations lead selectively to C2‐ and C3‐alkynylated indoles. The processes show excellent functional group tolerance, do not require additional heating and proceed under solventless conditions. Compared to solvent‐based standard protocols, the reaction times are shorter and the catalyst quantities lower resulting in high product yields under ambient atmosphere in mixer mills.
Under solventless conditions C2‐ and C3‐alkynylated indoles have been prepared in mixer mills by RhIII‐ and AuI‐catalyzed C−H alkynylations, respectively. Additional heating is not required, and both catalytic reactions show an excellent functional group tolerance. Compared to their solvent‐based counterparts, shorter reaction times and lower catalyst loadings are needed to provide high product yields.