Details

Autor(en) / Beteiligte

• Fang, Aiping
• Zhou, Shijie
• Su, Xiaolan
• Liu, Chuang
• Chen, Xiaoxin
• Wan, Yang
• Lei, Xiaohong
• Xie, Linshen
• Jia, Yiping
• Wang, Wenzhi
• Yang, Luo
• Song, Xuejiao
• Yao, Yuqin

Titel

RAMP3 is a prognostic indicator of liver cancer and might reduce the adverse effect of TP53 mutation on survival

Ist Teil von

• Future oncology (London, England), 2018-10, Vol.14 (25), p.2615-2625

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• To assess the prognostic value of RAMP3 expression in terms of overall survival (OS) and recurrence-free survival (RFS) in hepatocellular carcinoma (HCC) patients. Immunochemistry staining was performed to detect RAMP3 expression. Data in the Cancer Genome Atlas-Liver Hepatocellular Cancer were used for secondary analysis. RAMP3 expression was significantly downregulated in HCC tissues than in normal liver tissues. Increased RAMP3 expression was an independent prognostic factor of favorable OS (hazard ratio [HR]: 0.772, 95% CI: 0.689-0.864; p < 0.001) and RFS (HR = 0.719, 95% CI: 0.633-0.817; p < 0.001). High RAMP3 expression was associated with significantly better RFS in both TP53 mutant and wildtype groups. High RAMP3 RNA expression is an independent prognostic factor of favorable OS and RFS in patients with HCC.