The Lancet (British edition), 2009-03, Vol.373 (9668), p.1052-1052
2009
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Details
- Autor(en) / Beteiligte
- Titel
- Loss of sight and sound. Could it be the hip?
- Ist Teil von
- The Lancet (British edition), 2009-03, Vol.373 (9668), p.1052-1052
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- [...] in April, 2008, resection arthroplasty was done. Cobalt can produce various toxicological effects including local respiratory symptoms due to inhalation of cobalt containing dusts, and systemic effects (thyroiditis, cardiomyopathy, erythropoiesis).1 Neuro logical toxicity, mainly optic atrophy, nerve deafness, and limb paraesthesia, has been occasionally reported in association with exogenous exposure.2,3 Neuro logical toxicity as a reult of endogenous exposure (mainly associated with metal prostheses) has been described.4 Cobalt can induce a hypoxia-like effect, possibly targeting mitochondria; of note, our patient's symptoms were similar to those observed in some mitochondrial cytopathies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0140-6736eISSN: 1474-547XDOI: 10.1016/S0140-6736(09)60490-6Titel-ID: cdi_proquest_miscellaneous_20519057
- Format
- –
- Schlagworte
- Arthroplasty, Replacement, Hip, Biological and medical sciences, Blindness - etiology, Chromium - blood, Chromium - poisoning, Cobalt, Cobalt - blood, Cobalt - poisoning, Diabetes, Diabetes Mellitus, Type 2 - complications, Drug Overdose, Female, General aspects, Hearing Loss - etiology, Hip Prosthesis - adverse effects, Humans, Hypertension - complications, Hypothyroidism, Hypoxia, Inhalation, Internal Medicine, Joint surgery, Medical sciences, Middle Aged, Optic Nerve - drug effects, Prosthesis Failure, Reoperation, Vestibulocochlear Nerve - drug effects