The New England journal of medicine, 2018-06, Vol.378 (25), p.2386-2398
- DiNardo, Courtney D
- Stein, Eytan M
- de Botton, Stéphane
- Roboz, Gail J
- Altman, Jessica K
- Mims, Alice S
- Swords, Ronan
- Collins, Robert H
- Mannis, Gabriel N
- Pollyea, Daniel A
- Donnellan, Will
- Fathi, Amir T
- Pigneux, Arnaud
- Erba, Harry P
- Prince, Gabrielle T
- Stein, Anthony S
- Uy, Geoffrey L
- Foran, James M
- Traer, Elie
- Stuart, Robert K
- Arellano, Martha L
- Slack, James L
- Sekeres, Mikkael A
- Willekens, Christophe
- Choe, Sung
- Wang, Hongfang
- Zhang, Vickie
- Yen, Katharine E
- Kapsalis, Stephanie M
- Yang, Hua
- Dai, David
- Fan, Bin
- Goldwasser, Meredith
- Liu, Hua
- Agresta, Sam
- Wu, Bin
- Attar, Eyal C
- Tallman, Martin S
- Stone, Richard M
- Kantarjian, Hagop M
2018
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- Autor(en) / Beteiligte
- DiNardo, Courtney D
- Stein, Eytan M
- de Botton, Stéphane
- Roboz, Gail J
- Altman, Jessica K
- Mims, Alice S
- Swords, Ronan
- Collins, Robert H
- Mannis, Gabriel N
- Pollyea, Daniel A
- Donnellan, Will
- Fathi, Amir T
- Pigneux, Arnaud
- Erba, Harry P
- Prince, Gabrielle T
- Stein, Anthony S
- Uy, Geoffrey L
- Foran, James M
- Traer, Elie
- Stuart, Robert K
- Arellano, Martha L
- Slack, James L
- Sekeres, Mikkael A
- Willekens, Christophe
- Choe, Sung
- Wang, Hongfang
- Zhang, Vickie
- Yen, Katharine E
- Kapsalis, Stephanie M
- Yang, Hua
- Dai, David
- Fan, Bin
- Goldwasser, Meredith
- Liu, Hua
- Agresta, Sam
- Wu, Bin
- Attar, Eyal C
- Tallman, Martin S
- Stone, Richard M
- Kantarjian, Hagop M
- Titel
- Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML
- Ist Teil von
- The New England journal of medicine, 2018-06, Vol.378 (25), p.2386-2398
- Ort / Verlag
- United States: Massachusetts Medical Society
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Among patients with IDH1 -mutated relapsed or refractory leukemia, daily oral ivosidenib, an IDH1 inhibitor, induced molecular clearance of leukemic cells from bone marrow in 21% of patients and was associated with transfusion independence and a low rate of serious adverse events.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa1716984Titel-ID: cdi_proquest_miscellaneous_2049945150
- Format
- –
- Schlagworte
- Acute myeloid leukemia, Administration, Oral, Adolescent, Adult, Aged, Aged, 80 and over, Cancer therapies, Cell Count, Collaboration, Dose-Response Relationship, Drug, Drug dosages, Drug Resistance, Neoplasm, Enzyme Inhibitors - administration & dosage, Enzyme Inhibitors - adverse effects, Enzyme Inhibitors - pharmacokinetics, FDA approval, Female, Follow-Up Studies, Glycine - administration & dosage, Glycine - adverse effects, Glycine - analogs & derivatives, Glycine - pharmacokinetics, Hemoglobins - analysis, Humans, Investigations, Isocitrate dehydrogenase, Isocitrate Dehydrogenase - antagonists & inhibitors, Isocitrate Dehydrogenase - genetics, Leukemia, Leukemia, Myeloid, Acute - drug therapy, Leukemia, Myeloid, Acute - genetics, Leukemia, Myeloid, Acute - mortality, Leukocytosis, Male, Middle Aged, Mutation, Myeloid leukemia, Neutropenia, Patients, Point mutation, Pyridines - administration & dosage, Pyridines - adverse effects, Pyridines - pharmacokinetics, Recurrence, Remission, Remission Induction, Survival Rate, Thrombocytopenia, Tumors, Young Adult