Details

Autor(en) / Beteiligte

• Dhamodharan, V
• Nomura, Yoko
• Dwidar, Mohammed
• Yokobayashi, Yohei

Titel

Optochemical control of gene expression by photocaged guanine and riboswitches

Ist Teil von

• Chemical communications (Cambridge, England), 2018, Vol.54 (48), p.6181-6183

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Optical control of biomolecules via engineered proteins or photoactive small molecules has had a profound impact on biology. However, optochemical tools to control RNA functions in living cells are relatively limited. We synthesized a photoactivatable (photocaged) guanine to modulate gene expression under riboswitch control in both mammalian cells and Escherichia coli by light.