Details

Autor(en) / Beteiligte

• Belvindrah, Richard
• Graus-Porta, Diana
• Goebbels, Sandra
• Nave, Klaus-Armin
• Mueller, Ulrich

Titel

beta 1 Integrins in Radial Glia But Not in Migrating Neurons Are Essential for the Formation of Cell Layers in the Cerebral Cortex

Ist Teil von

• The Journal of neuroscience, 2007-12, Vol.27 (50), p.13854-13865

Erscheinungsjahr

2007

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Radial glial cells in the cerebral cortex serve as progenitors for neurons and glia and guide the migration of cortical neurons. The integrin alpha 3 beta 1 is thought to mediate interactions of migrating neurons with radial glial cells and to function as a receptor for the reelin signaling molecule. Here, we challenge this view and demonstrate that beta 1 integrins in migrating neurons are not essential for the formation of cell layers in the cerebral cortex. Cortical cell layers also form normally in mice deficient in the integrin alpha 3 beta 1. However, we provide evidence that beta 1 integrins in radial glia control the morphological differentiation of both glia and neurons. We conclude that beta 1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas beta 1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling.