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Does the environment influence multiple sclerosis pathogenesis via UVB light and/or induction of vitamin D?
Ist Teil von
Journal of neuroimmunology, 2019-04, Vol.329, p.1-8
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2019
Link zum Volltext
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Multiple sclerosis (MS) is a disease of presumed auto-immune origin. Long-standing observations such as the correlation between MS incidence and geographical latitude or the levels of Vitamin D (Vit D) in the serum have implicated the environmental factors UVB radiation and diet in the etiology of the disease. Clinical trials have been conducted and are currently underway to elucidate whether a Vit D enriched diet or treatment with UVB can influence MS incidence, −severity, and −progression, as well as the ideal time point for treatment. This review summarizes the current scientific knowledge to the environmental factors UVB-light and Vit D concerning the clinical aspects of MS in epidemiological studies and clinical trials.
•Low Vitamin D levels are associated with MS susceptibility and –progression.•UVB light is involved in MS etiology and progression independent from Vitamin D.•Clinical aspects of UVB light and Vitamin D in epidemiological and clinical studies.•α-MSH as an environmental mimetic for the development of novel MS therapeutics.