Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1694-1697
- EMMITTE, Kyle A
- ADJEBANG, George M
- JACKSON, Jeffrey R
- KUNTZ, Kevin W
- LANSING, Timothy J
- MOOK, Robert A
- NAILOR, Kristen E
- POBANZ, Mark A
- SMITH, Stephon C
- SUNG, Chiu-Mei
- CHEUNG, Mui
- WEBB ANDREWS, C
- BADIANG ALBERTI, Jennifer G
- BAMBAL, Ramesh
- CHAMBERLAIN, Stanley D
- DAVIS-WARD, Ronda G
- DICKSON, Hamilton D
- HASSLER, Daniel F
- HORNBERGER, Keith R
2009
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- Autor(en) / Beteiligte
- EMMITTE, Kyle A
- ADJEBANG, George M
- JACKSON, Jeffrey R
- KUNTZ, Kevin W
- LANSING, Timothy J
- MOOK, Robert A
- NAILOR, Kristen E
- POBANZ, Mark A
- SMITH, Stephon C
- SUNG, Chiu-Mei
- CHEUNG, Mui
- WEBB ANDREWS, C
- BADIANG ALBERTI, Jennifer G
- BAMBAL, Ramesh
- CHAMBERLAIN, Stanley D
- DAVIS-WARD, Ronda G
- DICKSON, Hamilton D
- HASSLER, Daniel F
- HORNBERGER, Keith R
- Titel
- Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1694-1697
- Ort / Verlag
- Amsterdam: Elsevier
- Erscheinungsjahr
- 2009
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modifications.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2009.01.094Titel-ID: cdi_proquest_miscellaneous_20452319
- Format
- –
- Schlagworte
- Antineoplastic agents, Biological and medical sciences, Cell Cycle, Cell Cycle Proteins - antagonists & inhibitors, Cell Cycle Proteins - chemistry, Cell Line, Tumor, Chemistry, Pharmaceutical - methods, Drug Design, General aspects, Humans, Inhibitory Concentration 50, Medical sciences, Mitosis, Models, Chemical, Molecular Conformation, Pharmacology. Drug treatments, Polo-Like Kinase 1, Protein Binding, Protein Kinase Inhibitors - chemical synthesis, Protein Kinase Inhibitors - pharmacology, Protein Serine-Threonine Kinases - antagonists & inhibitors, Protein Serine-Threonine Kinases - chemistry, Proto-Oncogene Proteins - antagonists & inhibitors, Proto-Oncogene Proteins - chemistry, Solubility, Thiophenes - chemistry, Tumor Suppressor Proteins