Details

Autor(en) / Beteiligte

• Hauschild, Axel
• Kähler, Katharina C.
• Schäfer, Martin
• Fluck, Michael

Titel

Interdisciplinary management recommendations for toxicity associated with interferon-alfa therapy

Ist Teil von

• Journal der Deutschen Dermatologischen Gesellschaft, 2008-10, Vol.6 (10), p.829-837

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

2008

Quelle

Access via Wiley Online Library

Beschreibungen/Notizen

• Summary Adjuvant interferon‐α (IFN‐α) therapy in patients with melanoma has been established as standard therapy since more than 10 years.During IFN‐α therapy, flu‐like symptoms, gastrointestinal disorders, arthralgias and neuropsychiatric symptoms are the most common side effects. The management and prophylaxis of these side effects have been improved by a more detailed understanding of pathophysiologic mechanisms and increased clinical experience. New insights in the relevance of detection of autoantibodies and development of autoimmunity have influenced the clinical pathway substantially. This review covers the pathomechanisms, incidence and optimized therapy of IFN‐α‐associated side effects.