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Interdisciplinary management recommendations for toxicity associated with interferon-alfa therapy
Ist Teil von
Journal der Deutschen Dermatologischen Gesellschaft, 2008-10, Vol.6 (10), p.829-837
Ort / Verlag
Oxford, UK: Blackwell Publishing Ltd
Erscheinungsjahr
2008
Link zum Volltext
Quelle
Wiley Online Library All Journals
Beschreibungen/Notizen
Summary
Adjuvant interferon‐α (IFN‐α) therapy in patients with melanoma has been established as standard therapy since more than 10 years.During IFN‐α therapy, flu‐like symptoms, gastrointestinal disorders, arthralgias and neuropsychiatric symptoms are the most common side effects. The management and prophylaxis of these side effects have been improved by a more detailed understanding of pathophysiologic mechanisms and increased clinical experience. New insights in the relevance of detection of autoantibodies and development of autoimmunity have influenced the clinical pathway substantially. This review covers the pathomechanisms, incidence and optimized therapy of IFN‐α‐associated side effects.