Details

Autor(en) / Beteiligte

• Pu, X-Y
• Liang, J-P
• Wang, X-H
• Xu, T
• Hua, L-Y
• Shang, R-F
• Liu, Y
• Xing, Y-M

Titel

Anti-Influenza A Virus Effect of Hypericum perforation L. Extract

Ist Teil von

• Virologica Sinica, 2009-02, Vol.24 (1), p.19-27

Erscheinungsjahr

2009

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• To study the antiviral effect of Hypericum perforatum L. extract (HPE) on influenza A virus (IAV) (H sub(1)N sub(1)) in vitro and in vivo. Cytopathic effect (CPE) and neutral red (NR) dye uptake were used to examine the antiviral effect of HPE on Madin Darby Canine Kidney (MDCK) cells which were infected with IAV in vitro. HPE was effective against influenza A virus (LAV) in vitro, with a 50% effective concentration (EC sub(50)) of 40 kg/mL. The mean 50% cytotoxic concentration (CC sub(50)) in the MDCK used in these experiments was 1.5 mg/mL. Ribavirin was run in parallel with EC sub(50) values of 5.0 kg/mL; the mean CC sub(50) for ribavirin was 520 kg/mL. Oral gavage administrations of HPE or ribavirin to mice infected with the IAV were highly effective in preventing death, slowing the decline of arterial oxygen saturation, inhibiting lung consolidation and reducing lung virus titers. The minimum effective dose of HPE in these studies was 31.25 mg/kg/day, which was administered twice daily for 5 d beginning