Details

Autor(en) / Beteiligte

• Quintana, J. M.
• González, N.
• Lázaro, S.
• Baré, M.
• Fernández‐de‐Larrea, N.
• Redondo, M.
• Briones, E.
• Escobar, A.
• Sarasqueta, C.
• García‐Gutierrez, S.
• Antón‐Ladislao, A.
• Mañas, Marisa Baré
• Bautista, Maximino Redondo
• Blanca, Eduardo Briones Pérez
• Ruiz, Francisco Rivas
• Morales‐Suárez‐Varela, Maria M.
• Amaro, Juan Antonio Blasco
• Cura González, Isabel
• Madariaga, Inmaculada Arostegui
• González, Amaia Bilbao
• Quintana, Josefa Ferreiro
• Hernández, Nerea González
• Guerrero, Iratxe Lafuente
• Larracoechea, Urko Aguirre
• Calzada, Miren Orive
• Corral, Josune Martin
• Antón‐Ladislao, Ane
• Torà, Núria
• Pont, Marina
• Prado, Marí Purificació Martínez
• Totorikaguena, Alberto Loizate
• Estévez, Ignacio Zabalza
• Alustiza, José Errasti
• Gimeno García, Antonio Z
• Serrano, Mercè Comas
• Navascues, Jose Marí Enríquez
• Galán, Carlos Placer
• Perales, Amaia
• Valmaña, Iñki Urkidi
• Azkárate, Jose María Erro
• Lizarribar, Enrique Cormenzana
• Muñoa, Adelaida Lacasta
• Pibernat, Pep Piera
• Cuevas, Elena Campano
• Gómez, Ana Isabel Sotelo
• Gómez‐Abril, Segundo
• Medina‐Cano, F.
• Alcaide, Julia
• Rey‐Moreno, Arturo Del
• Alcántara, Manuel Jesús
• Campo, Rafael
• Casalots, Alex
• Pericay, Carles
• Gil, Maria José
• Pera, Miquel
• Collera, Pablo
• Espinàs, Josep Alfons
• Martínez, Mercedes
• Espallargues, Mireia
• Almazán, Caridad
• Lindenbaum, Paula Dujovne
• Fernández‐Cebrián, José María
• Fernández, Rocío Anula
• Martínez, Julio Ángel Mayol
• Cid, Ramón Cantero
• Labajo, Héctor Guadalajara
• Garceau, María Heras
• Olmo, Damián García
• Montalvo, Mariel Morey

Titel

Predictors of 1‐ and 2‐year mortality in patients with rectal cancer

Ist Teil von

• Colorectal disease, 2018-08, Vol.20 (8), p.676-687

Ort / Verlag

England: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Aim Tools are needed to aid in the assessment of the prognosis of patients with rectal cancer regarding the risk of medium‐term mortality. The aim of this study was to develop and validate clinical prediction rules for 1‐ and 2‐year mortality in patients undergoing surgery for rectal cancer. Method A prospective cohort study of patients diagnosed with rectal cancer who underwent surgery was carried out. The main outcomes were mortality at 1 and 2 years after surgery. Background, clinical parameters and diagnostic test findings were evaluated as possible predictors. Multivariable survival models were used in the statistical analyses. Results Predictors of 1‐year mortality were being a current smoker [hazard ratio (HR) 4.98], having a Charlson index adjusted by age > 5 (HR 2.61), the presence of vascular, perineural or lymphatic invasion (HR 3.30), the presence of residual tumour at the operation (R‐stage) (HR 8.64) and TNM stage (HR for TNM IV 5.10) [concordance index (C‐index) 0.799 (95% CI: 0.71–0.89)]. Age greater than 80 years (HR 2.19), being a current smoker (HR 2.20), the pre‐intervention haemoglobin level (HR 2.02), need for blood transfusion (HR 2.12), vascular, perineural or lymphatic invasion (HR 2.59), R‐stage of the operation (HR 6.13) and TNM stage (HR for TNM IV 4.43) were predictors of 2‐year mortality [C‐index 0.779 (0.718–0.840)]. Adjuvant chemotherapy was an additional predictor at both outcome durations. Conclusion These clinical parameters show good predictive values and are easy and quick‐to‐use tools to help in clinical decision making.