Biochemical pharmacology, 2018-08, Vol.154, p.170-173
2018
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- Autor(en) / Beteiligte
- Titel
- Exploiting methionine restriction for cancer treatment
- Ist Teil von
- Biochemical pharmacology, 2018-08, Vol.154, p.170-173
- Ort / Verlag
- England: Elsevier Inc
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- [Display omitted] Normal cells can synthesize sufficient methionine for growth requirements from homocysteine and 5-methyltetrahydrofolate and vitamin B12. However, many cancer-cell types require exogenous methionine for survival and therefore methionine restriction is a promising avenue for treatment. While the lack of the methionine salvage enzyme methylthioadenosine phosphorylase (MTAP) deficiency is associated with methionine dependence in cancer cells, there are other causes for tumors to require exogenous methionine. In this review we describe studies that show restricting methionine to certain cancers by diet or by enzyme depletion, alone or in combination with certain chemotherapeutics is a promising antitumor strategy. The basis for methionine dependence in tumor cells is also briefly reviewed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-2952eISSN: 1873-2968DOI: 10.1016/j.bcp.2018.05.003Titel-ID: cdi_proquest_miscellaneous_2036201452
- Format
- –
- Schlagworte
- 5-Methyltetrahydrofolate, Animals, Antineoplastic Agents - metabolism, Antineoplastic Agents - therapeutic use, Clinical Trials as Topic - methods, Humans, Methioninase, Methionine, Methionine - metabolism, Methionine - therapeutic use, Methionine restriction, MTAP, Neoplasms - drug therapy, Neoplasms - metabolism, Purine-Nucleoside Phosphorylase - metabolism, Tetrahydrofolates - metabolism, Treatment Outcome, Tumor Cells, Cultured, Vitamin B12