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Predictive and mechanistic multivariate linear regression models for reaction development
Ist Teil von
Chemical science (Cambridge), 2018-03, Vol.9 (9), p.2398-2412
Ort / Verlag
England: Royal Society of Chemistry
Erscheinungsjahr
2018
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Multivariate Linear Regression (MLR) models utilizing computationally-derived and empirically-derived physical organic molecular descriptors are described in this review. Several reports demonstrating the effectiveness of this methodological approach towards reaction optimization and mechanistic interrogation are discussed. A detailed protocol to access quantitative and predictive MLR models is provided as a guide for model development and parameter analysis.
The utilization of physical organic molecular descriptors for the quantitative description of reaction outcomes in multivariate linear regression models is demonstrated as an effective tool for
a priori
prediction and mechanistic interrogation.