Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.1018-1021
- Emmitte, Kyle A.
- Andrews, C. Webb
- Badiang, Jennifer G.
- Davis-Ward, Ronda G.
- Dickson, Hamilton D.
- Drewry, David H.
- Emerson, Holly K.
- Epperly, Andrea H.
- Hassler, Daniel F.
- Knick, Victoria B.
- Kuntz, Kevin W.
- Lansing, Timothy J.
- Linn, James A.
- Mook, Robert A.
- Nailor, Kristen E.
- Salovich, James M.
- Spehar, Glenn M.
- Cheung, Mui
2009
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- Autor(en) / Beteiligte
- Emmitte, Kyle A.
- Andrews, C. Webb
- Badiang, Jennifer G.
- Davis-Ward, Ronda G.
- Dickson, Hamilton D.
- Drewry, David H.
- Emerson, Holly K.
- Epperly, Andrea H.
- Hassler, Daniel F.
- Knick, Victoria B.
- Kuntz, Kevin W.
- Lansing, Timothy J.
- Linn, James A.
- Mook, Robert A.
- Nailor, Kristen E.
- Salovich, James M.
- Spehar, Glenn M.
- Cheung, Mui
- Titel
- Discovery of thiophene inhibitors of polo-like kinase
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.1018-1021
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2009
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2008.11.041Titel-ID: cdi_proquest_miscellaneous_20341306
- Format
- –
- Schlagworte
- Animals, Antineoplastic agents, Benzimidazole, Biological and medical sciences, Cell Cycle, Cell Cycle Proteins - antagonists & inhibitors, Cell Cycle Proteins - chemistry, Cell Line, Tumor, Cell Proliferation, Chemistry, Pharmaceutical - methods, Drug Design, Enzyme Inhibitors - chemical synthesis, Enzyme Inhibitors - pharmacology, General aspects, Humans, Inhibitor, Inhibitory Concentration 50, Medical sciences, Mice, Mitosis, Models, Chemical, Molecular Conformation, Pharmacology. Drug treatments, Polo-like kinase, Polo-Like Kinase 1, Protein Serine-Threonine Kinases - antagonists & inhibitors, Protein Serine-Threonine Kinases - chemistry, Proto-Oncogene Proteins - antagonists & inhibitors, Proto-Oncogene Proteins - chemistry, Thiophene, Thiophenes - antagonists & inhibitors, Thiophenes - chemistry