Details

Autor(en) / Beteiligte

• Jeong, W.I. (Kyungpook National Univ., Taegu (Korea R.))
• Jeong, D.H
• Do, S.H
• Kim, Y.K
• Park, H.Y
• Kwon, O.D
• Kim, T.H
• Jeong, K.S

Titel

Mild hepatic fibrosis in cholesterol and sodium cholate diet-fed rats

Ist Teil von

• Journal of Veterinary Medical Science, 2005, Vol.67(3), pp.235-242

Ort / Verlag

Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• To date, the majority of research on hypercholesterolemia has focused on the effects of a high cholesterol diet on atheroscle-rosis and coronary heart disease. The toxic effects of cholesterol on the liver and the relationship between the intake of a high cholesterol diet and hepatic fibrosis, however, have not been investigated cleas1y or histopethologically. Male Wistar rats were fed a dici supple-mented with 1.0% cholesterol and 0.3% sodium cholate for 12 weeks. Rats were sacnftced and analyzed via blood biochemistry, tradi-tional microscopy and immunohistochmistry. Following the feeding of this diet, the rates of asparsaze aminoiransferase. alanine aminotransfersac, Lactate dehydrogenase and total cholesterol in the rats were elevated consistently from week 3 and throughout the remainder of the experiment. From microscopic observation. hepatic necrosis. macropliage infiltration and steatosis increased markedly throughout the expenment Hepatic fibrosis and myofibmblast proliferation were detected at weeks 9 and 12. Mast cell appearance was proportional to the degree of hepatic damage. These findings suggest that hepatic fibrosis is inducible by a high cholesterol diet and is likely the result of the interaction between several different cell types (i.e., macrophages, myofibroblasts. and mast cells) in an inflame-matcay milieu. Hypercholesterolemia should be considered as a risk factor for hepatic fibrosis as well as atherosclerosis and coronary artery disease.