Details

Autor(en) / Beteiligte

• Simon, Anna J
• Walls-Smith, Luke T
• Plaxco, Kevin W

Titel

Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel

Ist Teil von

• Analyst (London), 2018-06, Vol.143 (11), p.2531-2538

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• The sequence-specific hybridization and molecular recognition properties of DNA support the construction of stimulus-responsive hydrogels with precisely controlled crosslink geometry. Here we show that, as predicted by the conformational selection mechanism, the response kinetics of such a hydrogel can be tuned over orders of magnitude by modulating the thermodynamic stability of its crosslinks.