Details

Autor(en) / Beteiligte

• Frauenrath, Herbert
• Brethauer, Dirk
• Reim, Stefan
• Maurer, Martin
• Raabe, Gerhard

Titel

Highly Enantioselective Isomerization of 4,7-Dihydro-1,3-dioxepins Catalyzed by Me-DuPHOS-Modified Dihalogenonickel Complexes and Determination of the Absolute Configuration of the Isomerization Products

Ist Teil von

• Angewandte Chemie (International ed.), 2001-01, Vol.40 (1), p.177-179

Ort / Verlag

Weinheim: WILEY-VCH Verlag GmbH

Erscheinungsjahr

2001

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A breakthrough in the asymmetric isomerization of 4,7‐dihydro‐1,3‐dioxepins 1 was achieved by using DuPHOS‐modified dihalogenonickel complexes such as 4 as catalyst precursors. The absolute configurations of the isomerization products were determined by transforming 2 into 2‐hydroxy‐γ‐butyrolactone 3 and 1,2,4‐butanetriol through a new oxidation‐ring contraction sequence. The relative configuration of the oxidation product 5 was established by crystal structure analysis.