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Extracorporeal CO2 Removal May Improve Renal Function of Patients with Acute Respiratory Distress Syndrome and Acute Kidney Injury: An Open-Label, Interventional Clinical Trial
Ist Teil von
American journal of respiratory and critical care medicine, 2018-09, Vol.198 (5), p.687-690
Ort / Verlag
New York: American Thoracic Society
Erscheinungsjahr
2018
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
To the Editor: Attenuation of inflammatory and apoptotic responses in patients with acute respiratory distress syndrome (ARDS) has been associated with a reduction in end-organ failure and the improvement in outcome observed with conventional protective ventilation (1). [...]although differences between groups were minimized by the adopted matching method, small and not significant differences in creatinine values (2.82 6 1.04 vs. 3.49 6 1.15 mg/dl in RRT 1 and RRT, respectively; P = 0.14) and KDIGO class II (number of patients = 2 [15%] vs. 1 [8%] in RRT1 and RRT, respectively; P = 0.99) and class III (number of patients = 11 [85%] vs. 12 [92%] in RRT1 and RRT, respectively; P = 0.99) were still observed. [...]the nonrandomized design and unmeasured residual confounders may systematically overestimate the magnitude of the beneficial effects and the safety profile of RRT1. ? Safety and efficacy of combined extracorporeal CO2 removal and renal replacement therapy in patients with acute respiratory distress syndrome and acute kidney injury: the Pulmonary and Renal Support in Acute Respiratory Distress Syndrome study.