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If a paper is posted on a noncommercial archival server such as bioRxiv, the paper will be examined on a case-by-case basis to determine whether the submitted version ofthe manuscript has substantial new information compared with the already posted one. [...]listing a manuscript on a preprint server will reduce its chances of being considered (e.g., Journal of Clinical Oncology, British Medical Journal, and the Journal of the American Medical Association). Findings from clinical trials may be sought after and read by caregivers, patients, and other laypersons who lack the ability to critically evaluate the information. [...]editors of medical journals, rightly so, are more hesitant to encourage the availability ofsuch information before the appropriate vetting during the peer review process. The journal presents a broad spectrum of topics including novel technologies, critical evaluations of laboratory diagnostic applications and approaches, and multicenter clinical trial findings demonstrating the optimal utility of laboratory tests in various pathologies. [...]Clinical Chemistry bridges the basic and medical sciences.