Details

Autor(en) / Beteiligte

• Espiritu, Shadrielle Melijah G.
• Liu, Lydia Y.
• Rubanova, Yulia
• Bhandari, Vinayak
• Holgersen, Erle M.
• Szyca, Lesia M.
• Fox, Natalie S.
• Chua, Melvin L.K.
• Yamaguchi, Takafumi N.
• Heisler, Lawrence E.
• Livingstone, Julie
• Wintersinger, Jeff
• Yousif, Fouad
• Lalonde, Emilie
• Rouette, Alexandre
• Salcedo, Adriana
• Houlahan, Kathleen E.
• Li, Constance H.
• Huang, Vincent
• Fraser, Michael
• van der Kwast, Theodorus
• Morris, Quaid D.
• Bristow, Robert G.
• Boutros, Paul C.

Titel

The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression

Ist Teil von

• Cell, 2018-05, Vol.173 (4), p.1003-1013.e15

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• The majority of newly diagnosed prostate cancers are slow growing, with a long natural life history. Yet a subset can metastasize with lethal consequences. We reconstructed the phylogenies of 293 localized prostate tumors linked to clinical outcome data. Multiple subclones were detected in 59% of patients, and specific subclonal architectures associate with adverse clinicopathological features. Early tumor development is characterized by point mutations and deletions followed by later subclonal amplifications and changes in trinucleotide mutational signatures. Specific genes are selectively mutated prior to or following subclonal diversification, including MTOR, NKX3-1, and RB1. Patients with low-risk monoclonal tumors rarely relapse after primary therapy (7%), while those with high-risk polyclonal tumors frequently do (61%). The presence of multiple subclones in an index biopsy may be necessary, but not sufficient, for relapse of localized prostate cancer, suggesting that evolution-aware biomarkers should be studied in prospective studies of low-risk tumors suitable for active surveillance. [Display omitted] •The phylogenies of 293 localized prostate cancers were reconstructed•Multiple subclones were detected in 59% of patients•Specific genes are selectively mutated early or late in tumor evolution•Subclonal architecture adds prognostic ability to previously developed biomarkers Tumors evolve during their natural life history. We studied the evolution of newly diagnosed prostate tumors and identified specific genes mutated early or late in a tumor’s life history. Considering subclonality improved predictions of disease aggressivity, identifying those patients who might be good candidates for receiving less treatment.