Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Ergebnis 4 von 442
Veterinary record, 2018-06, Vol.182 (25), p.717-717
2018

Details

Autor(en) / Beteiligte
Titel
First report of prion-related protein gene (PRNT) polymorphisms in cattle
Ist Teil von
  • Veterinary record, 2018-06, Vol.182 (25), p.717-717
Ort / Verlag
England: BMJ Publishing Group Limited
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Access via Wiley Online Library
Beschreibungen/Notizen
  • Prion diseases are caused by structural changes in normal prion protein (PrPC). The prion gene family includes four members: prion protein (PRNP), prion-like protein (PRND), shadow of PRNP (SPRN) and prion-related protein (PRNT). Genetic association studies of prion diseases and the other genes in the prion gene family, except for PRNT, have been performed in cattle. Our previous studies indicated that the distribution of PRNP promoter polymorphisms related with bovine spongiform encephalopathy susceptibility is significantly different in Hanwoo (Korean native cattle) and Holstein cattle. However, PRNT polymorphisms have not been reported thus far in cattle. Hence, we examined the PRNT single nucleotide polymorphisms (SNPs) in 315 Hanwoo and 140 Holstein cattle. We found a total of two SNPs, PRNT c.-87C>T and PRNT c.-37G>C, in the 5’ untranslated region of exon 2. The c.-87C>T and c.-37G>C genotype (P<0.0001) and allele (P<0.0001) frequencies exhibited significant differences in the distribution between Hanwoo and Holstein cattle. In addition, the c.-37G<C polymorphism was not found in Hanwoo. Interestingly, we did not find any polymorphisms in the ORF of bovine PRNT, which is in contrast with the highly polymorphic ovine PRNT ORF region. This is the first genetic research of the PRNT gene in cattle.
Sprache
Englisch
Identifikatoren
ISSN: 0042-4900
eISSN: 2042-7670
DOI: 10.1136/vr.104123
Titel-ID: cdi_proquest_miscellaneous_2027071981

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX