Details

Autor(en) / Beteiligte

• Chen, Ru-jie
• Guo, Xian-yang
• Cheng, Bi-huan
• Gong, Yu-qiang
• Ying, Bin-yu
• Lin, Meng-xiang

Titel

Saikosaponin a Inhibits Cigarette Smoke-Induced Oxidant Stress and Inflammatory Responses by Activation of Nrf2

Ist Teil von

• Inflammation, 2018-08, Vol.41 (4), p.1297-1303

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2018

Quelle

SpringerLink

Beschreibungen/Notizen

• Saikosaponin a (SSa), a triterpenoid saponin, has numerous pharmacological properties, including anti-inflammatory and antioxidant effects. The purpose of this study was to investigate whether and how SSa protected against cigarette smoke (CS)-induced lung inflammation in mice. The mice were exposed to CS and SSa was administered by an intraperitoneal (i.p.) injection 1 h before CS treatment for 5 consecutive days. The results showed that SSa significantly inhibited CS-induced inflammatory cell infiltration, NO, TNF-α, and IL-1β production in BALF. SSa also inhibited CS-induced MPO and MDA contents in lung tissues. Furthermore, SSa significantly inhibited CS-induced NF-κB and upregulated the expression of Nrf2 and HO-1. In conclusion, these results support a therapeutic potential for SSa in CS-induced lung inflammation.