Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1911-1914
2018
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- Autor(en) / Beteiligte
- Titel
- Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp
- Ist Teil von
- Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1911-1914
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2018
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- [Display omitted] Callyspongiamides A (1) and B (2), two new sterol O-acyltransferase (SOAT) inhibitors, were isolated from the Indonesian marine sponge Callyspongia sp. together with a known congener, dysamide A (3). The structures of 1 and 2 were elucidated to be polychlorine-containing modified dipeptides based on their spectroscopic data. Compounds 1–3 inhibited both of the SOAT isozymes, SOAT1 and SOAT2, in cell-based and enzyme-based assays.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0960-894XeISSN: 1464-3405DOI: 10.1016/j.bmcl.2018.03.077Titel-ID: cdi_proquest_miscellaneous_2023726150
- Format
- –
- Schlagworte
- Animals, Callyspongia - chemistry, Callyspongia - metabolism, Callyspongiamide, Dipeptides - chemistry, Dipeptides - isolation & purification, Dipeptides - pharmacology, Enzyme Assays, Enzyme Inhibitors - chemistry, Enzyme Inhibitors - isolation & purification, Enzyme Inhibitors - pharmacology, Indonesia, Inhibitor, Inhibitory Concentration 50, Isoenzymes - antagonists & inhibitors, Isoenzymes - metabolism, Magnetic Resonance Spectroscopy, Marine sponge Callyspongia sp, Molecular Conformation, Polychlorine-containing modified dipeptide, Sterol O-acyltransferase, Sterol O-Acyltransferase - antagonists & inhibitors, Sterol O-Acyltransferase - metabolism