Details

Autor(en) / Beteiligte

• McDowell, Christina L.
• Bryan Sutton, R.
• Obermann, Wolfgang M.J.

Titel

Expression of Hsp90 chaperome proteins in human tumor tissue

Ist Teil von

• International journal of biological macromolecules, 2009-10, Vol.45 (3), p.310-314

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2009

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The activity of many oncogenic proteins depends on the molecular chaperone Hsp90. Recent studies indicate that tumorigenesis is associated with increased expression of chaperones, such as Hsp90. However, little is known about the isoform dependence and cochaperone contribution on tumor formation. Here we report the first systematic expression profiling for Hsp90α and Hsp90β, the cochaperones Aha1, Cdc37, p23, Tpr2, and the Hsp90 dependent transcription factor HSF1 in a set of different tumor tissue samples. We find that in 10 out of 17 human tumors the expression level of at least one Hsp90 or Hsp90 cochaperone protein is significantly elevated. However, individual tumors show unique patterns of expression. Furthermore, Hsp90α and Hsp90β expression levels are not related. Our results suggest that expression profiling of Hsp90α and Hsp90β and its cochaperone proteins may be useful for cancer diagnosis and prognosis as well as for tailoring of drugs that interfere with the Hsp90 system in a tumor specific manner.