Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
[Display omitted]
•Eight new C21 steroidal glycosides (1–8) were isolated from the roots of Cynanchum otophyllum.•The substitutes of tigloyl, 4-methyl-2-pentenoyl, and vanilloyl at C-12 were first identified from this species.•Compared to the positive control, compounds 5, 9–11 exhibited more potential inhibitory activity against MCF-7 cells.
Eight new C21 steroidal glycosides, namely cynanotins A–H (1–8), together with fifteen known analogues, were isolated from the roots of Cynanchum otophyllum. Their structures were elucidated by spectroscopic analysis and chemical methods. In this study, all of isolates were tested for their vitro inhibitory activities against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7 and SW480). Compounds 3–15 showed moderate cytotoxic activities against HL-60 cell lines with IC50 values ranging from 11.4 to 37.9 µM. Compounds 5, 9, and 10 showed marked or moderate cytotoxic activities against five human tumor cell lines with IC50 values ranging from 11.4 to 36.7 µM. Compound 11 displayed moderate cytotoxic activities against HL-60, SMMC-7721, MCF-7 and SW480 cell lines with IC50 values of 12.2–30.8 µM. Compared to the positive control (IC50: 35.0 µM), compounds 5, 9–11 exhibited more potential inhibitory activity against MCF-7 cells (IC50: 16.1–25.6 µM).