Details

Autor(en) / Beteiligte

• Kalitin, K. Yu
• Grechko, O. Yu
• Spasov, A. A.
• Sukhov, A. G.
• Anisimova, V. A.
• Matukhno, A. E.

Titel

GABAergic Mechanism of Anticonvulsive Effect of Chemical Agent RU-1205

Ist Teil von

• Bulletin of experimental biology and medicine, 2018-03, Vol.164 (5), p.629-635

Ort / Verlag

New York: Springer US

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The study examined the effect of 9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo[1,2-α] benzimidazole dihydrochloride (RU-1205) on the latency of seizures provoked by corazol, bicuculline, or picrotoxin. This agent (10 and 20 mg/kg) increased the seizure latency in the experimental models of epileptogenesis. The blockers of GABA A and GABA A -ρ receptors picrotoxin and (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid, respectively, were employed to study the effects of RU-1205 on electrical activity of somatosensory cortical neurons and on formation of pathological rhythms in the rat brain. RU-1205 inhibited the focal background rhythm and eliminated the epileptiform activity, which can be mediated by interaction with GABA A receptors.