Details

Autor(en) / Beteiligte

• Mueller, Stefanie H.
• Färber, Anna
• Golombeck, Kristin S.
• Kümpfel, Tania
• Kaufmann, Max
• Ringelstein, Marius
• Kellinghaus, Christoph
• Ehrlich, Sven
• Then Bergh, Florian
• Faiss, Jürgen H.
• Franke, Andre
• Lyss, Birgit
• Wallenfelsova, Eva
• Othman, Jalal
• Bogarin, Yuri
• Schwabe, Julia
• Handreka, Robert
• Rostasy, Kevin
• Körber, Rüdiger
• Heide, Wolfgang
• Geis, Tobias
• Dogan, Muejgan
• Bien, Christian
• Kramme, Corinna
• Pulkowski, Ulrich
• Hoepner, Robert
• Schindler, Kaspar
• Lippert, Julian
• Ewering, Carina
• Reimann, Gemot
• Schimrigk, Sebastian
• Urbanek, Christian
• Schön, Frauke
• Finke, Alexander
• Henningsen, Henning
• Küpper, Philipp
• Hofstadt, Ulrich
• Trendelenburg, George
• Heider, Steffen
• Thaler, Franziska
• Muth, Carolin
• Borggräfe, Ingo
• Blaschek, Astrid
• Bieniek, Rolf
• Philipsen, Alexandra
• Winter, Benjamin
• Gass, Achim
• Hagenah, Ulrich
• Hausler, Martin Georg
• Tauber, Simone
• Elger, Christian
• Spruth, Eike
• Paul, Friedemann
• Finke, Carsten
• Prüss, Harald
• Wöpking, Sigrid
• Schneider, Auke
• Seitz, Rüdiger
• Aktas, Orhan
• Huttner, Hagen
• Stich, Oliver
• Baumgartner, Annette
• Neubauer, Bemd
• Döppner, Thorsten
• Süße, M
• Heesen, Christoph
• Friese, Manuel
• Sühs, Kurt‐Wolfram
• Trebst, Corinna
• Wildemann, Brigitte
• Bösel, Julian
• Roepke, Luise
• Brämer, Dirk
• Strubl, Julia
• Günther, Albrecht
• Bergh, Florian Then
• Schilling, Ruth
• Bittner, Daniel
• Spreer, Annette
• Methner, Axel
• Pledl, Hans‐Wemer
• Anlonso, Angelika
• Szabo, Kristina
• Philipp, Konstanze
• Möning, Constanze
• Weissert, Robert
• Retzlaff, Nele
• Fousse, Mathias
• Ragoschke‐Schumm, Andreas
• Stumer, Klarissa
• Berg, Daniela
• Schmütz, Isa
• Bartsch, Thorsten
• Falk, Kim Christin
• Hummel, Katja
• Tumani, Hayrettin
• Lewerenz, Jan

Titel

Genetic predisposition in anti‐LGI1 and anti‐NMDA receptor encephalitis

Ist Teil von

• Annals of neurology, 2018-04, Vol.83 (4), p.863-869

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• We performed a genome‐wide association study in 1,194 controls and 150 patients with anti‐N‐methyl‐D‐aspartate receptor (anti‐NMDAR, n = 96) or anti‐leucine‐rich glioma‐inactivated1 (anti‐LGI1, n = 54) autoimmune encephalitis. Anti‐LGI1 encephalitis was highly associated with 27 single‐nucleotide polymorphisms (SNPs) in the HLA‐II region (leading SNP rs2858870 p = 1.22 × 10−17, OR = 13.66 [7.50–24.87]). Potential associations, below genome‐wide significance, were found with rs72961463 close to the doublecortin‐like kinase 2 gene (DCLK2) and rs62110161 in a cluster of zinc‐finger genes. HLA allele imputation identified association of anti‐LGI1 encephalitis with HLA‐II haplotypes encompassing DRB1*07:01, DQA1*02:01 and DQB1*02:02 (p < 2.2 × 10−16) and anti‐NMDAR encephalitis with HLA‐I allele B*07:02 (p = 0.039). No shared genetic risk factors between encephalitides were identified. Ann Neurol 2018;83:863–869