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Selenium nanocomposites as multifunctional nanoplatform for imaging guiding synergistic chemo-photothermal therapy
Ist Teil von
Colloids and surfaces, B, Biointerfaces, 2018-06, Vol.166, p.161-169
Ort / Verlag
Netherlands: Elsevier B.V
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals
Beschreibungen/Notizen
[Display omitted]
•The nanocomposite exhibited excellent fluorescence imaging performance.•The nanocomposite as carrier for co-loading ICG and DOX.•Triple treatment of photothermal therapy and chemotherapy for selenium and DOX.•The nanocomposite as a nanoplatform for multimodal imaging guiding synergistic treatment.
A multifunctional selenium nanocomposite (selenium@silica core-shell nanoshperes for loading indocyanine green(ICG)/Doxorubicin(DOX)) was fabricated to reach visible and efficient cancer treatment. The Se@SiO2-ICG nanocomposites could be used not only as excellent photothermal agents but also as carriers for DOX delivery. In addition, the Se@SiO2-ICG/DOX nanocomposites exhibited excellent fluorescence imaging and infrared imaging performance. Tumor could be effectively inhibited by Se@SiO2-ICG/DOX due to the triple treatment of photothermal effect and chemotherapy of selenium and DOX. Thus, the Se@SiO2-ICG/DOX nanocomposites have a great potential in imaging guiding synergistic treatment of cancer.