Details

Autor(en) / Beteiligte

• Cristinelli, Sara
• Ciuffi, Angela

Titel

The use of single-cell RNA-Seq to understand virus–host interactions

Ist Teil von

• Current opinion in virology, 2018-04, Vol.29, p.39-50

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2018

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• [Display omitted] •Single cell analyses reveal cell heterogeneity, often masked at population level.•ScRNA-Seq identifies transcriptomic signatures hallmarking distinct cell subsets.•ScRNA-Seq coupled with phenotypic analyses uncovers specific cell subsets.•Subsets with unique molecular signatures are relevant for virus-host interactions.•ScRNA-Seq coupled with phenotypic analyses is a valuable tool in virology. Single-cell analyses allow uncovering cellular heterogeneity, not only per se, but also in response to viral infection. Similarly, single cell transcriptome analyses (scRNA-Seq) can highlight specific signatures, identifying cell subsets with particular phenotypes, which are relevant in the understanding of virus–host interactions.