Details

Autor(en) / Beteiligte

• Cabanillas, Alejandro
• Davies, Christopher D
• Male, Louise
• Simpkins, Nigel S

Titel

Highly enantioselective access to diketopiperazines via cinchona alkaloid catalyzed Michael additions

Ist Teil von

• Chemical science (Cambridge), 2015-02, Vol.6 (2), p.1350-1354

Ort / Verlag

England

Erscheinungsjahr

2015

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Michael addition reactions of triketopiperazine (TKP) derivatives to enones, mediated by a cinchona alkaloid-derived catalyst, deliver products in high yield and enantiomeric ratio (er). Use of unsaturated ester, nitrile or sulfone partners gives bridged hydroxy-diketopiperazine (DKP) products resulting from a novel Michael addition-ring closure.