Details

Autor(en) / Beteiligte

• Gong, X Y
• Wang, Y
• Liu, B C
• Wei, H
• Li, C W
• Li, Q H
• Zhao, J W
• Zhou, C L
• Lin, D
• Liu, K Q
• Wei, S N
• Gong, B F
• Zhang, G J
• Liu, Y T
• Zhao, X L
• Li, Y
• Gu, R X
• Qiu, S W
• Mi, Y C
• Wang, J X

Titel

Characteristics and prognosis in adult acute myeloid leukemia patients with MLL gene rearrangements

Ist Teil von

• Zhōnghuá xuèyèxué zázhì, 2018-01, Vol.39 (1), p.9

Ort / Verlag

China

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• To analyze the clinical and laboratory characteristics, and prognosis of adult acute myeloid leukemia (AML) patients with MLL gene rearrangements. The medical records of 92 adult AML patients with MLL gene rearrangements from January 2010 to December 2016 were retrospectively analyzed. 92 cases (6.5%) with MLL gene rearrangements were identified in 1 417 adult AML (Non-M(3)) patients, the median age of the patients was 35.5 years (15 to 64 years old) with an equal sex ratio, the median WBC were 21.00(0.42-404.76)×10(9)/L, and 78 patients (84.8%) were acute monoblastic leukemia according to FAB classification. Eleven common partner genes were detected in 32 patients, 9 cases (28.1%) were MLL/AF9(+), 5 cases (15.6%) were MLL/AF6(+), 5 cases (15.6%) were MLL/ELL(+), 2 cases (6.3%) were MLL/AF10(+), 1 case (3.1%) was MLL/SETP6(+), and the remaining 10 patients' partner genes weren't identified. Of 92 patients, 83 cases with a median follow-up of 10.3 (0.3-74.0) months were included for the prognosis analysis, the