Details

Autor(en) / Beteiligte

• Uchiyama, Seiichi
• Tsuji, Toshikazu
• Kawamoto, Kyoko
• Okano, Kentaro
• Fukatsu, Eiko
• Noro, Takahiro
• Ikado, Kumiko
• Yamada, Sayuri
• Shibata, Yuka
• Hayashi, Teruyuki
• Inada, Noriko
• Kato, Masaru
• Koizumi, Hideki
• Tokuyama, Hidetoshi

Titel

A Cell‐Targeted Non‐Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium‐Containing Cationic Radical Initiator

Ist Teil von

• Angewandte Chemie International Edition, 2018-05, Vol.57 (19), p.5413-5417

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A cationic fluorescent nanogel thermometer based on thermo‐responsive N‐isopropylacrylamide and environment‐sensitive benzothiadiazole was developed with a new azo compound bearing imidazolium rings as the first cationic radical initiator. This cationic fluorescent nanogel thermometer showed an excellent ability to enter live mammalian cells in a short incubation period (10 min), a high sensitivity to temperature variations in live cells (temperature resolution of 0.02–0.84 °C in the range 20–40 °C), and remarkable non‐cytotoxicity, which permitted ordinary cell proliferation and even differentiation of primary cultured cells. A fluorescent nanogel thermometer was prepared with a cationic radical initiator. This thermometer is able to enter live mammalian cells within a short incubation period (10 min), a high sensitivity to temperature variations in live cells (temperature resolution of 0.02–0.84 °C), and remarkable non‐cytotoxicity, which permitted ordinary cell proliferation and differentiation of primary cultured cells.