Details

Autor(en) / Beteiligte

• Sherman, S. Murray

Titel

My prolonged collaboration with Ray Guillery

Ist Teil von

• The European journal of neuroscience, 2019-04, Vol.49 (7), p.928-937

Ort / Verlag

France: Wiley Subscription Services, Inc

Erscheinungsjahr

2019

Quelle

Psychology & Behavioral Sciences Collection

Beschreibungen/Notizen

• My active collaboration with Ray Guillery started in 1968, when he was a Full Professor at the University of Wisconsin and I was a graduate student at the University of Pennsylvania. The collaboration lasted almost 50 years with virtually no breaks. Among the ideas we proposed are that glutamatergic pathways in thalamus and cortex can be classified into drivers and modulators; that many thalamic nuclei could be classified as higher order, meaning that they receive driving input from layer 5 of cortex and participate in cortico‐thalamocortical circuits; and that much of the information relayed by thalamus serves as an efference copy for motor commands initiated by cortex. Ray and I worked together developing ideas regarding thalamocortical circuitry, and three stand out. First, glutamatergic pathways, which dominate thalamic and cortical circuitry, include two very different classes, which we called driver and modulator; we suggested that driver pathways carry the main information to be processed and that modulator pathways modulate how driver inputs are processed. Second, based on the driver inputs to thalamus, we identified two types of thalamic relay: first order, which receive driver input from a subcortical source (e.g. retinal input to the lateral geniculate nucleus) and higher order, which receive driver input from layer 5 of one cortical area and relay that input to another cortical area. Third, because driver input to thalamus (both first and higher orders) often if not always involves a branching axon that also innervates extrathalamic motor structures in the brainstem, we suggested that driver information relayed by thalamus could be treated as an efference copy.