Details

Autor(en) / Beteiligte

• Zhu, Yu‐Chao
• Li, Yan
• Zhang, Bo‐Chao
• Zhang, Feng‐Xu
• Yang, Yi‐Nuo
• Wang, Xi‐Sheng

Titel

Palladium‐Catalyzed Enantioselective C−H Olefination of Diaryl Sulfoxides through Parallel Kinetic Resolution and Desymmetrization

Ist Teil von

• Angewandte Chemie International Edition, 2018-04, Vol.57 (18), p.5129-5133

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The first example of PdII‐catalyzed enantioselective C−H olefination with non‐chiral or racemic sulfoxides as directing groups was developed. A variety of chiral diaryl sulfoxides were synthesized with high enantioselectivity (up to 99 %) through both desymmetrization and parallel kinetic resolution (PKR). This is the first report of PdII‐catalyzed enantioselective C(sp2)−H functionalization through PKR, and it represents a novel strategy to construct sulfur chiral centers. A PdII‐catalyzed enantioselective C−H olefination with non‐chiral or racemic sulfoxides as directing groups was developed. A variety of chiral diaryl sulfoxides were synthesized with high enantioselectivity through both desymmetrization and parallel kinetic resolution (PKR). This is the first reported PdII‐catalyzed enantioselective C(sp2)−H functionalization through PKR, and it represents a novel strategy to construct sulfur chiral centers.