Details

Autor(en) / Beteiligte

• Brumpton, Ben M.
• Langhammer, Arnulf
• Henriksen, Anne H.
• Romundstad, Pål R.
• Chen, Yue
• Camargo, Carlos A.
• Mai, Xiao-Mei

Titel

Serum 25-hydroxyvitamin D, vitamin D supplement and asthma control: The HUNT study

Ist Teil von

• Respiratory medicine, 2018-03, Vol.136, p.65-70

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Few studies have investigated the association between serum 25-hydroxyvitamin D (25[OH]D), vitamin D supplement and asthma control among adults. We aimed to examine whether low levels of serum 25(OH)D or not taking vitamin D supplement were associated with an increased risk of poorly controlled asthma among Norwegian adults with asthma. We used a definition of asthma control adapted from the Global Initiative for Asthma. We first examined cross-sectional associations between serum 25(OH)D (n = 806) or vitamin D supplement (n = 1179) and poorly controlled asthma. Next, among those with well controlled asthma at baseline, we examined prospective associations between serum 25(OH)D (n = 147) or vitamin D supplement (n = 208) and poorly controlled asthma at follow-up, approximately 11 years later. We estimated risk ratios (RR) and 95% confidence intervals (CI) with Poisson regression. The adjusted RR for poorly controlled asthma was 1.00 (95% CI, 0.89–1.13) for adults with serum 25(OH)D < 50 nmol/L in cross-sectional and 1.50 (95% CI, 0.46–4.95) in prospective analyses. The adjusted RR for poorly controlled asthma was 1.17 (95% CI 1.00–1.37) for non-users of vitamin D supplement in cross-sectional and 1.66 (95% CI 0.49–5.67) in prospective analyses. Our study did not show strong evidence that among adults with asthma, having a low serum 25(OH)D or being a non-user of vitamin D supplement was associated with an increased risk of poorly controlled asthma. Some point estimates indicated an increased risk, however our estimates were generally imprecise and further evidence is needed. •Few studies have investigated vitamin D, vitamin D supplement and asthma control.•We examined both cross-sectional and prospective associations.•Some point estimates indicated an increased risk, however estimates were imprecise.•Overall, we did not find strong evidence of an association.