Details

Autor(en) / Beteiligte

• Conrad, Curdin
• Boyman, Onur
• Tonel, Giulia
• Tun-Kyi, Adrian
• Laggner, Ute
• De Fougerolles, Antonin
• Kotelianski, Victor
• Gardner, Humphrey
• Nestle, Frank O

Titel

[alpha] sub(1)[beta] sub(1) integrin is crucial for accumulation of epidermal T cells and the development of psoriasis

Ist Teil von

• Nature medicine, 2007-07, Vol.13 (7), p.836-842

Erscheinungsjahr

2007

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Psoriasis is a common T cell-mediated autoimmune inflammatory disease. We show that blocking the interaction of [alpha] sub(1)[beta] sub(1) integrin (VLA- 1) with collagen prevented accumulation of epidermal T cells and immunopathology of psoriasis. [alpha] sub(1)[beta] sub(1) integrin, a major collagen-binding surface receptor, was exclusively expressed by epidermal but not dermal T cells. [alpha] sub(1)[beta] sub(1)-positive T cells showed characteristic surface markers of effector memory cells and contained high levels of interferon-[gamma] but not interleukin-4. Blockade of [alpha] sub(1)[beta] sub(1) inhibited migration of T cells into the epidermis in a clinically relevant xenotransplantation model. This was paralleled by a complete inhibition of psoriasis development, comparable to that caused by tumor necrosis factor-[alpha] blockers. These results define a crucial role for [alpha] sub(1)[beta] sub(1) in controlling the accumulation of epidermal type 1 polarized effector memory T cells in a common human immunopathology and provide the basis for new strategies in psoriasis treatment focusing on T cell-extracellular matrix interactions.