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We investigated correlation between the normal level of air pollution, weather conditions and stroke occurrence in the region of Southeast Europe with a humid continental climate. This retrospective study included 1963 patients, 1712 (87.2%) with ischemic (IS) and 251 (12.8%) with hemorrhagic stroke (HS) admitted to emergency department. The number of patients, values of weather condition (meteorological parameters) [air temperature (°C), atmospheric pressure (kPa), relative humidity (%)] and concentrations of air pollutants [particulate matter (PM
10
), nitrogen dioxide (NO
2
), ozone (O
3
)], were recorded and evaluated for each season (spring, summer, autumn, winter) during 2 years (July 2008–June 2010). The highest rate of IS was observed during spring (28.9%) (
p
= 0.0002) and HS in winter (33.9%) (
p
= 0.0006). We have found negative Spearman’s correlations (after Bonferroni adjustment for the multiple correlations) of the number of males with values of relative humidity (%) (day 0, rho = − 0.15), the total number of strokes (day 2, rho = − 0.12), females (day 2, rho = − 0.12) and IS (day 2, rho = − 0.13) with concentrations of PM
10
(µg/m
3
), as well as negative correlations of the number of females (day 2, rho = − 0.12) and IS (day 2, rho = − 0.12) with concentrations of NO
2
(µg/m
3
) (for all
p
< 0.002). In winter, the number of HS (day 0, rho = 0.25,
p
= 0.001) positively correlated with concentrations of O
3
(µg/m
3
). The appearance of stroke has seasonal variations, with the highest rates during spring and winter. Positive correlation between the number of HS and values of O
3
requires an additional reduction of the legally permitted pollutants concentrations.