Details

Autor(en) / Beteiligte

• Kaneko, Hiroto
• Taniwaki, Masafumi
• Matsumoto, Yosuke
• Yoshida, Mihoko
• Shimura, Kazuho
• Fujino, Takahiro
• Uchiyama, Hitoji
• Kuroda, Junya

Titel

An adult-onset case of chronic active Epstein-Barr virus infection with fulminant clinical course

Ist Teil von

• Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2018-06, Vol.24 (6), p.479-482

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A 56-year-old Japanese male with chronic active Epstein-Barr virus (EBV) infection (CAEBV) who developed systemic gamma-delta T-cell lymphoproliferative disease (LPD) is reported. Although immune cooling therapy was effective, he died of sudden and severe hypoxia and anemia soon after the initiation of cytotoxic chemotherapy that had been previously recommended. There might remain a difficulty to control fulminant adult-onset CAEBV. Additionally, we describe three types of lymphoid cells that were observed in his peripheral blood: morphologically normal lymphocytes, large blastic cells and mature ones with rough granules. Morphological observation appeared to be useful to estimate clinical manifestations. Since CAEBV is extremely rare disease in adult population, it is important to accumulate clinical data to more understand the pathogenesis or to establish treatment strategy.