Details

Autor(en) / Beteiligte

• Hvilsom, Gitte Bjørn
• Londero, Stefano Christian
• Hahn, Christoffer Holst
• Schytte, Sten
• Pedersen, Henrik Baymler
• Christiansen, Peer
• Kiss, Katalin
• Larsen, Stine Rosenkilde
• Jespersen, Marie Louise
• Lelkaitis, Giedrius
• Godballe, Christian

Titel

Anaplastic thyroid carcinoma in Denmark 1996–2012: A national prospective study of 219 patients

Ist Teil von

• Cancer epidemiology, 2018-04, Vol.53, p.65-71

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• •A prospectiv, nationwide cohort study of 219 Danish Anaplastic Thyroid Carcinoma patients.•Characteristics, incidence, prognostic factors, and introduction of a fast track cancer program were evaluated.•“Respiratory impairment at diagnosis” and “introduction of a national fast track cancer program” are added as prognostic indicators for ATC. Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients. A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014. We found the median age in the 7th decade, the majority of patients being women presenting with a growing mass at the neck, diagnosed with stage T4b disease. At diagnosis, 56% of the patients had lymph node metastasis and 38% distant metastasis. We observed one- and five-year survival of 20.7% and 11.0%, respectively. Both univariate and multivariate analyses showed age (above 73.6 years), respiratory impairment, T4b stage, and distant metastasis at diagnosis to be significant prognostic factors. Further, introduction of a national fast track cancer program increased survival nearly two-fold. As new information, our study adds “respiratory impairment at diagnosis” and “introduction of a national fast track cancer program” to the list of already established prognostic indicators for ATC.