Details

Autor(en) / Beteiligte

• Konno, Takuya
• Deutschländer, Angela
• Heckman, Michael G.
• Ossi, Maryam
• Vargas, Emily R.
• Strongosky, Audrey J.
• van Gerpen, Jay A.
• Uitti, Ryan J.
• Ross, Owen A.
• Wszolek, Zbigniew K.

Titel

Comparison of clinical features among Parkinson's disease subtypes: A large retrospective study in a single center

Ist Teil von

• Journal of the neurological sciences, 2018-03, Vol.386, p.39-45

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Tremor dominant (TD), postural instability/gait difficulty (PIGD), and akinetic-rigid (AR) subtypes are widely used in classifying patients with Parkinson's disease (PD). We compared clinical characteristics between PD subtypes in a large retrospective cohort. Between 1998 and 2016, we included a total of 1003 patients with PD in this retrospective study. Six hundred ninety-four patients had more than one visit. Data were collected regarding motor/non-motor symptoms at the initial/final visits. Based on the prominent symptom at the initial visit, we classified patients into one of the four subtypes: TD, AR, gait difficulty, and mixed. Rapid progression was defined by emergence of falls, dementia, or dependency within 5years after onset. TD was the most prevalent subtype (44%), followed by AR (29%), mixed (18%), and gait difficulty (9%). Rapid progression was observed more frequently in gait difficulty compared to AR (OR: 3.59 P<0.001). Hallucinations at the final visit were more likely to occur in AR (OR: 2.36, P=0.005) and mixed (OR: 3.28, P<0.001) compared to TD. Our findings provide support for a distinction of four different PD subtypes: TD, AR, gait difficulty, and mixed. The gait difficulty subtype was distinguishable from the AR subtype. •We present retrospective study of PD subtypes performed in a single center.•We use tremor dominant (TD), akinetic-rigid (AR), gait difficulty, and mixed subtypes.•Rapid progression is more likely in gait difficulty subtype compared to AR subtype.•Hallucinations develop more frequently in AR and mixed subtypes than in TD subtype.•Gait difficulty subtype can be distinguished from AR subtype.