Details

Autor(en) / Beteiligte

• Braddock, D. Christopher
• Lickiss, Paul D
• Rowley, Ben C
• Pugh, David
• Purnomo, Teresa
• Santhakumar, Gajan
• Fussell, Steven J

Titel

Tetramethyl Orthosilicate (TMOS) as a Reagent for Direct Amidation of Carboxylic Acids

Ist Teil von

• Organic letters, 2018-02, Vol.20 (4), p.950-953

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Tetramethyl orthosilicate (TMOS) is shown to be an effective reagent for direct amidation of aliphatic and aromatic carboxylic acids with amines and anilines. The amide products are obtained in good to quantitative yields in pure form directly after workup without the need for any further purification. A silyl ester as the putative activated intermediate is observed by NMR methods. Amidations on a 1 mol scale are demonstrated with a favorable process mass intensity.