Details

Autor(en) / Beteiligte

• Krug, David
• Baumann, René
• Budach, Wilfried
• Dunst, Jürgen
• Feyer, Petra
• Fietkau, Rainer
• Haase, Wulf
• Harms, Wolfgang
• Hehr, Thomas
• Piroth, Marc D.
• Sedlmayer, Felix
• Souchon, Rainer
• Wenz, Frederik
• Sauer, Rolf

Titel

Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer: A systematic review

Ist Teil von

• Strahlentherapie und Onkologie, 2018-07, Vol.194 (7), p.607-618

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2018

Quelle

Springer Online Journals【Remote access available】

Beschreibungen/Notizen

• Purpose To review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response. Methods A systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1 st  January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy. Results Out of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports. Conclusions There is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B‑51/RTOG 1304 and Alliance A11202 are eagerly awaited.