Details

Autor(en) / Beteiligte

• Schupp, Jonas Christian
• Freitag-Wolf, Sandra
• Bargagli, Elena
• Mihailović-Vučinić, Violeta
• Rottoli, Paola
• Grubanovic, Aleksandar
• Müller, Annegret
• Jochens, Arne
• Tittmann, Lukas
• Schnerch, Jasmin
• Olivieri, Carmela
• Fischer, Annegret
• Jovanovic, Dragana
• Filipovic, Snežana
• Videnovic-Ivanovic, Jelica
• Bresser, Paul
• Jonkers, René
• O'Reilly, Kate
• Ho, Ling-Pei
• Gaede, Karoline I
• Zabel, Peter
• Dubaniewicz, Anna
• Marshall, Ben
• Kieszko, Robert
• Milanowski, Janusz
• Günther, Andreas
• Weihrich, Anette
• Petrek, Martin
• Kolek, Vitezslav
• Keane, Michael P
• O'Beirne, Sarah
• Donnelly, Seamas
• Haraldsdottir, Sigridur Olina
• Jorundsdottir, Kristin B
• Costabel, Ulrich
• Bonella, Francesco
• Wallaert, Benoît
• Grah, Christian
• Peroš-Golubičić, Tatjana
• Luisetti, Mauritio
• Kadija, Zamir
• Pabst, Stefan
• Grohé, Christian
• Strausz, János
• Vašáková, Martina
• Sterclova, Martina
• Millar, Ann
• Homolka, Jiří
• Slováková, Alena
• Kendrick, Yvonne
• Crawshaw, Anjali
• Wuyts, Wim
• Spencer, Lisa
• Pfeifer, Michael
• Valeyre, Dominique
• Poletti, Venerino
• Wirtz, Hubertus
• Prasse, Antje
• Schreiber, Stefan
• Krawczak, Michael
• Müller-Quernheim, Joachim

Titel

Phenotypes of organ involvement in sarcoidosis

Ist Teil von

• The European respiratory journal, 2018-01, Vol.51 (1), p.1700991-1700991

Ort / Verlag

England: European Respiratory Society Journals Ltd

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Sarcoidosis is a highly variable, systemic granulomatous disease of hitherto unknown aetiology. The GenPhenReSa (Genotype-Phenotype Relationship in Sarcoidosis) project represents a European multicentre study to investigate the influence of genotype on disease phenotypes in sarcoidosis.The baseline phenotype module of GenPhenReSa comprised 2163 Caucasian patients with sarcoidosis who were phenotyped at 31 study centres according to a standardised protocol.From this module, we found that patients with acute onset were mainly female, young and of Scadding type I or II. Female patients showed a significantly higher frequency of eye and skin involvement, and complained more of fatigue. Based on multidimensional correspondence analysis and subsequent cluster analysis, patients could be clearly stratified into five distinct, yet undescribed, subgroups according to predominant organ involvement: 1) abdominal organ involvement, 2) ocular-cardiac-cutaneous-central nervous system disease involvement, 3) musculoskeletal-cutaneous involvement, 4) pulmonary and intrathoracic lymph node involvement, and 5) extrapulmonary involvement.These five new clinical phenotypes will be useful to recruit homogenous cohorts in future biomedical studies.