Details

Autor(en) / Beteiligte

• van Wijck, Yolanda
• de Kleijn, Stan
• John-Schuster, Gerrit
• Mertens, Tinne C J
• Hiemstra, Pieter S
• Müller, Anne
• Smits, Hermelijn H
• Taube, Christian

Titel

Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease

Ist Teil von

• The Journal of immunology (1950), 2018-03, Vol.200 (5), p.1570-1579

Ort / Verlag

United States: American Association of Immunologists

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Epidemiological and experimental studies have shown that exposure to the gastric bacterium , especially in early life, prevents the development of asthma. Recent mouse studies have shown that this protective effect does not require live bacteria and that treatment with an extract of in neonates prevents the development of airway inflammation and goblet cell metaplasia. In the current study, the effect of administration of an extract of was assessed in a therapeutic study design with application of the extract just prior to allergen challenge. C57BL/6 mice were sensitized and challenged with OVA or house dust mite. Treatment with extract just prior to the challenge significantly reduced airway inflammation, as assessed in bronchoalveolar lavage fluid and lung tissue, and reduced airway remodeling, as assessed by goblet cell quantification. These effects were apparent in the OVA model and in the house dust mite model. Injection of extract reduced the processing of allergen by dendritic cells in the lungs and mediastinal lymph node. Bone marrow-derived dendritic cells exposed to extract were affected with regard to their ability to process Ag. These data show that application of extract after sensitization effectively inhibits allergic airway disease.