Details

Autor(en) / Beteiligte

• van de Laar, Thijs J.
• Van Gaever, Véronique A.
• Swieten, Peter van
• Muylaert, An
• Compernolle, Veerle
• Zaaijer, Hans L.

Titel

Phylogenetic analysis reveals three distinct epidemiological profiles in Dutch and Flemish blood donors with hepatitis B virus infection

Ist Teil von

• Virology (New York, N.Y.), 2018-02, Vol.515, p.243-249

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• During 2006–2016, hepatitis B virus (HBV) was detected in nearly 400 blood donors in the Netherlands and Flanders. Donor demographics and self-reported risk factors as disclosed during the donor exit interview were compared to HBV phylogenies of donor and reference sequences. First-time donors with chronic HBV-infection were often immigrants (67%) infected with genetically highly diverse strains of genotypes A (32%), B (8%), C (6%), D (53%) and E to H (1%). Each subtype was strongly associated with donor ethnicity. In contrast, 57/62 (93%) of acute/recent HBV infections occurred among indigenous donors, of whom 67% was infected with one specific widely circulating epidemic HBV-A2 lineage. HBV typing identified three distinct epidemiological profiles: the import of chronic HBV infections through migration, longstanding transmission of non-epidemic HBV-A2 strains within western-Europe, and the active transmission of one epidemic HBV-A2 strain most likely fueled by sexual risk behavior. •HBV prevalence has significantly declined over the last decade.•HBV genotype is strongly associated with ethnicity.•Population migration is the main source of chronic HBV infections.•One homologous HBV-A2 lineage accounts for the majority of Incident HBV infections.•Phylogenetic analysis provides information on HBV risk factors and donor compliance.