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The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia
Ist Teil von
Bulletin of experimental biology and medicine, 2018, Vol.164 (3), p.298-303
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2018
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Hypoxia-induced immediate expression of transcription factor HIF-1α in the brain cortex is regulated by succinate produced in both the tricarbonic acid cycle and GABA shunt reactions and is induced by succinate-containing drugs. These facts prove the existence of succinate-dependent signalling regulation involved in immediate and delayed molecular adaptation and increased body resistance to oxygen deficiency, where succinate acts as a signal molecule. The intensity of this process differs in animals with low and high resistance to hypoxia.