Details

Autor(en) / Beteiligte

• Tang, Chunchao
• Gao, Yuqi
• Liu, Tingting
• Lin, Yuxing
• Zhang, Xiaomeng
• Zhang, Chaochao
• Li, Xiang
• Zhang, Tianchao
• Du, Lupei
• Li, Minyong

Titel

Bioluminescent probe for detecting endogenous hypochlorite in living mice

Ist Teil von

• Organic & biomolecular chemistry, 2018, Vol.16 (4), p.645-651

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• As a kind of biologically important reactive oxygen species (ROS), hypochlorite (ClO ) plays a crucial role in many physiological processes. As such, endogenous ClO is a powerful antibacterial agent during pathogen invasion. Nonetheless, excessive endogenous ClO could pose a health threat to mammalian animals including humans. However, the detection of endogenous ClO by bioluminescence probes in vivo remains a considerable challenge. Herein, based on a caged strategy, we developed a turn-on bioluminescent probe 1 for the highly selective detection of ClO in vitro and imaging endogenous ClO in a mouse inflammation model. We anticipate that such a probe could help us understand the role of endogenous ClO in a variety of physiological and pathological processes.