Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (8-9), p.911-915
2007
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Details
- Autor(en) / Beteiligte
- Titel
- Design, Enantiopure Synthesis, and Biological Evaluation of Novel ISO-D-2′,3′-Dideoxy-3′-Fluorothianucleoside Derivatives as a bioisostere of Lamivudine
- Ist Teil von
- Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (8-9), p.911-915
- Ort / Verlag
- United States: Taylor & Francis Group
- Erscheinungsjahr
- 2007
- Quelle
- Taylor & Francis
- Beschreibungen/Notizen
- Novel iso D-2′,3′-dideoxythianucleoside derivatives 1-3 were designed and asymmetrically synthesized to search for new anti-HIV agents. Final compounds 1-3 were evaluated against a variety of viruses including HIV-1 and 2. Only cytosine analog 3 showed a potent anti-VSV activity (EC 50 = 9.43 μ g/mL). This result implies that iso 2′,3′-dideoxy sugar templates might play a role of a sugar surrogate of nucleosides for the development of anti-RNA virus agent.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1525-7770eISSN: 1532-2335DOI: 10.1080/15257770701506426Titel-ID: cdi_proquest_miscellaneous_19892812
- Format
- –
- Schlagworte
- 2′-3′-dideoxy sugar templates, Animals, Anti-HIV agents, Anti-HIV Agents - chemical synthesis, Anti-HIV Agents - chemistry, Anti-HIV Agents - pharmacology, anti-VSV activity, Antiviral Agents - chemical synthesis, Antiviral Agents - chemistry, Antiviral Agents - pharmacology, Cell Line, Cercopithecus aethiops, Drug Design, HeLa Cells, HIV-1 - drug effects, HIV-2 - drug effects, Human immunodeficiency virus, Human immunodeficiency virus 1, Humans, Iso, Lamivudine - analogs & derivatives, Lamivudine - chemical synthesis, Lamivudine - chemistry, Lamivudine - pharmacology, Microbial Sensitivity Tests, Stereoisomerism, sulfur participation, Vero Cells, Vesicular stomatitis Indiana virus - drug effects